Vitamin B12 deficiencies cause damage brain and nervous system. Initial stage symptoms such as fatigue, depression and poor memory. A vitamin B12 deficiency is a disorder and indications of deficiency of vitamin b12 when they reach at high stage .fatigue, paleness, anorexia, mental confusion, delusions, paranoia, weight loss; respiratory problems are just some indications that a person may have a B12 Deficiency.

Vitamin B12 is important vitamin that we usually get from our food. It is found in meat and milk product. Vitamin B12 helps to make our red blood cell and keep our nervous system working.

Vitamin B12 deficiency may be big problem if inadequate absorption of nutrients in the digestive system. Hydrochloric acid in the stomach releases b12 from protein during digestion .B12 combines with a substance called intrinsic factor before it is absorbed into the bloodstream.

Vitamin B12 deficiency symptoms as many other treatable conditions may be virtually identical to age dementia symptoms, senile dementia symptoms and Alzheimer symptoms. In the age of 65 many people has low Vitamin B12.

Vitamin B12 Deficiency Symptoms are as following:-

  1. Paleness
  2. loss of appetite
  3. numbness and tingling of hands and feet
  4. shortness of breath
  5. fatigue
  6. weakness
  7. sore mouth
  8. sore tongue
  9. Confusion in mental status.

B12 maintain our nervous system and help nerve cells healthy.B12 also help in the production DNA.  Pregnant women need increased amount of B12 for proper fetal development. Diets may also a deficiency in the B12 in most people because they get it from food. Digestion problem may be cause of B12 deficiency.

Medical use and Treatment

Vitamin B12 tables and injection used in treatment of deficiency of Vitamin B12

These supplements carry such of vitamin that 1%  to 5% of high oral doses of free crystalline B12 is absorbed.

Recently  sublingual methylcobalamin in 1 mg tables. Physicians give Vitamin B12 Injections this  known as cobalamin or cyanocobalamin injections ,  to patients that are suffering from anemia, fatigue or other deficiency sysmptoms. Patients which have pernicious anemia require lifelong vitamin B12 injections and may want to consider

Dietary changes for b12 deficiency.

There are many side effects of these injections of vitamin B12. Some of are as:

Nausea, upset stomach, mild diarrhea, headache, joint pain etc.

There are other side effect of Injections which are uncommon and serious are :-

A heart palpitations, a rapid heartbeat, rapid weight gain, muscle weakness, muscle pain , muscle cramps, a feeling extreme thirst, frequent urination, leg pain a sense of confusion ,numbness, shortness of breath with mild exertion or when lying down, redness, pain or a feeling of warmth in one leg, tenderness or swelling in one leg, a red skin color on the face, a red skin color anywhere on the body ,hives, itching, skin rash etc may occur.

The two enzymatic reaction are dependent on vitamin b12 the first reaction, methylmalolonic acid is converted to succinyl1-CoA using vitamin b12 .the second reaction homocysteine is converted to methionine by using vitamin b-12 and folic acid.

The vitamin b12 deficiency based on low serum vitamin b12 level ,less than 200pg per mL, along with clinical evidence of disease.

This tells that the patients tend to present with neuropsychiatric disease in the absence of hematologic finding. and farther measurement of metabolites such as methylmalonic acid and homocysteine have been seen to be more sensitive in the vitamin b12 deficiency than measurement of serum b12 level alone. In the pernicious anemia injection is given for month to years.

The methylmalonic acid and homocysteine level diagnosis of vitamin b12 deficiency has found some surprising facts. almost 50% of patients have serum vitamin b12 level above 200pg per mL.


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